Survival analysis from the TCGA database showed that higher expression of candidate genes (CCNE2, CDCA5, RAD51, and MCM10) was associated with poor prognosis in the overall population of breast cancer patients (p < 0.05) (Figure 6A), whereas TCF19, KNTC1, and NEIL3 were not related to poor prognosis in the overall population of breast cancer patients (p > 0.05) (Supplementary Figure S1A). The gene discussed is CCNE2; the disease is breast cancer.