PIK3CA and cancer: Using the Oncodrive CLUST algorithm, we identified seven cancer driver genes from the TCGA-BRCA database, including (AKT1, KRAS, NADH: ubiquinone oxidoreductase core subunit S1 (NDUFS1), ribosomal protein L22 (RPL22), dipeptidase 1 (DPEP1), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and family with sequence similarity 102 member A (FAM102A)) (Figure 8A).