ERBB2 and breast cancer: We thus decided to focus our research on CXCR4/ACKR3 signaling and crosstalk mechanisms in the MDA-MB-361 BC cell model, a subtype characterized by lower basal levels of active ERK and high levels of EGFR and HER2 heterodimers, and which displayed a positive crosstalk of ErbB-RTKs and CXCR4/ACKR3 to the ERK pathway.