Among these polyphyllins, PPI has a significant therapeutic effect on hepatocellular carcinoma, CRC, melanoma, prostate cancer, and gastric cancer by inducing cell cycle arrest, apoptosis, and autophagy, as well as by inhibiting the activation of STAT3 and the PI3K/AKT/mTOR signaling pathways [11,12,13,14]. This evidence concerns the gene AKT1 and colorectal carcinoma.