The APOA5 locus was associated with three lipid disorders, and the associations were greatly and very significantly increased for all of them (hypercholesterolemia = OR: 1.11, p-value = 1.37 × 10−8; triglyceridemia = OR: 1.89, p-value = 5.01 × 10−228; and hypo-HDL-cholesterolemia = OR: 1.83, p-value = 3.80 × 10−164; Table 2). Here, APOA5 is linked to familial hypercholesterolemia.