The GCKR loci were significant for hypercholesterolemia and hypertriglyceridemia (CH-L4 and TG-L2, respectively); the APOB and ABCA1 loci were significantly associated with both hypercholesterolemia (CH-L3:APOB and CH-L10:ABCA1, respectively) and hypo-HDL cholesterolemia (HDL-L2:APOB and HDL-L9:ABCA1, respectively). The gene discussed is APOB; the disease is Hypercholesterolemia.