HLA-B and metabolic disease: This study was the first to find 15 of the significant loci associated with metabolic disorders: GO-L3:ITIH4 for general obesity; AB-L4:XKR3 for abdominal obesity; HTN-L6:HLAB and HTN-L18:LRRC30 for HTN; DM-L1:3p13 and DM-L9:7p12 for T2D; TG-L3:HSD17B13, TG-L4:VARS, and TG-L11:FSD2 for hypertriglyceridemia; HDL-L3:TSBP1, HDL-L7:TRPS1, and HDL-L8:9q21.31 for hypo-HDL cholesterolemia; MetS-L1:6q21, MetS-L2:COA1, and MetS-L3:HTR5A for MetS (Table 4).