Although in numerous cancer cell systems, NTS signaling depends on EGFR activation [56,57], this is not the case in HT29 cells, since sSortilin/NTSR3 is unable to compete with EGF on the EGFR, and reciprocally, EGF is unable to compete with sSortilin/NTSR3 on its binding sites [54]. This evidence concerns the gene EGFR and cancer.