SORT1 and colorectal cancer: In addition to its involvement in intracellular trafficking, Sortilin/NTSR3 also displays a receptor function for NTS [20], for a lipoprotein lipase [21], and a co-receptor function to initiate the action of NTS in pancreatic beta cells [22,23,24], as well as in the HT29 adenocarcinoma colorectal cancer cells [25,26].