In conclusion, our data for BCP-ALL patients and cell lines indicated predominant activity of aberrant IRX2 in subtype TCF3, of IRX3 in subtype ETV6, and of MEIS1 in subtype KMT2A, supporting a potential oncogenic role of these TALE-class homeobox genes in subsets of this malignancy. Here, IRX2 is linked to acute lymphoblastic leukemia.