IRX5 and acute myeloid leukemia: Using the myeloid TALE-code, we have recently detected physiological activity of TALE homeobox gene IRX1 exclusively in megakaryocyte erythroid progenitors (MEPs) during early myelopoiesis, and aberrant expression of IRX1, IRX3 and IRX5 in particular subtypes of acute myeloid leukemia (AML) [18].