BRCA1 and neoplasm: Furthermore, the results of the tumor-suppressing genes showed that when the MCF10A cells were treated with AB1, there was a reduction in the gene expression of BRCA1, BRCA2, and p53, and the decrease in BRCA1 expression suggests that AB1 affected BRCA1 expression and activity, which in turn affected the repair mechanism in the MCF10A cells [53].