Genome-wide association studies (GWAS) in multiple NAFLD cohorts have identified risk variants in genes, including patatin-like phospholipase domain-containing 3 (PNPLA3), membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), transmembrane 6 superfamily member 2 (TM6SF2), apolipoprotein C3 (APOC3), and glucokinase regulator GCKR [15,16]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.