PNPLA3 and Cirrhosis: The most validated so far is the variant p.I148M in 1-acylglycerol-3-phosphate O-acyltransferase (PNPLA3), associated with higher triglyceride levels, as well as with an increased risk of non-alcoholic steatohepatitis, cirrhosis decompensation, HCC development, and mortality [6,7,8,9].