Regarding mTOR pathway activation in ABC cells, we only observed reduced activation in cells transfected with both PLD1 and PLD2 siRNAs (a condition in which we observed a reduced PLD1 and PLD2 expression), and no difference was observed in cells transfected with only PLD1 siRNA in spite of the reduced PLD1 expression achieved. This evidence concerns the gene MTOR and aneurysmal bone cyst.