PLD1 and aneurysmal bone cyst: Regarding mTOR pathway activation in ABC cells, we only observed reduced activation in cells transfected with both PLD1 and PLD2 siRNAs (a condition in which we observed a reduced PLD1 and PLD2 expression), and no difference was observed in cells transfected with only PLD1 siRNA in spite of the reduced PLD1 expression achieved.