Self-assembling nanoparticles of fucoidan from L. japonica and a cationic polypeptide protamine were studied as doxorubicin carriers and found to have an improved inhibitory effect on metastatic breast cancer cells (MDA-MB-231 line) potentially associated with P-selectin recognition of fucoidan chains which promotes endocytosis [107]. This evidence concerns the gene SELP and breast cancer.