In one germline study performed on 130 patients with osteosarcoma treated with neoadjuvant cisplatin-based therapy in combination with doxorubicin, methotrexate, and ifosfamide the ERCC2 rs13181 and ERCC2 rs1799793 SNPs were associated with survival [28]. The gene discussed is ERCC2; the disease is osteosarcoma.