However, the genetic ablation of mast cells in the transgenic adenocarcinoma mouse prostate (TRAMP) model restores their capability to induce a tumor-specific cytotoxic T-cell response, which correlates (in KitWsh-TRAMP mice) with decreased activity of PMN-MDSCs and downregulated expression of Arg1, Stat3, and Nos2 [137]. Here, ARG1 is linked to neoplasm.