Several exosomal miRNAs, such as lncRNA-TP73- AS1 [151], miR-325 [152], miRNA-129-5p [153], miR-200a, miR-21, miR-325, miR-320a, and miR-505 [154,155], in tumors have been identified as modulators of HMGB1-mediated biological actions within the TME, including immune evasion, cell migration, and tumor metastasis, hence, facilitating cancer development [156]. The gene discussed is HMGB1; the disease is cancer.