For example, epidermal growth factor receptor (EGFR) enhances MAPK expression, promoting tumor cell proliferation and metastasis; fibroblast growth factor receptor (FGFR) increases PI3K/AKT expression, enhancing tumor angiogenesis; and hepatocyte growth factor receptor (HGFR or MET) enhances phosphorylated extracellular-signal-regulated kinase (ERK) expression, resulting in tumor survival and growth [11,12,13,14]. Here, AKT1 is linked to neoplasm.