We show here that the hyperammonemia-induced changes in GAD65 and GAD67, and in the membrane expression of GAT3, and of the γ2, α2, and β3 subunits of GABAA receptors are also reversed by blocking TNFR1 signaling, S1PR2, or CCR2. Here, TNFRSF1A is linked to Hyperammonemia.