Hyperammonemia increased the content of gephyrin (Figure 9A–D) and the phosphorylation of the β3 subunit of GABAA receptor (Figure 9E–H) in the cerebellum; these increases were reversed by blocking TrkB with ANA12, TNFR1 with R7050, S1PR2 with JTE-013, or CCR2 with RS504393. The gene discussed is NTRK2; the disease is Hyperammonemia.