Doxorubicin is relatively cytotoxic and may be employed in cancer; colchicine is well-tolerated and also regulates other genes involved in autophagy activation (transcription factor EB (TFEB), SQSTM1/p62, LC3), supporting that colchicine could represent a useful candidate to be tested in other misfolded protein-associated NDs [206,268]. This evidence concerns the gene TFEB and cancer.