TP53 and cancer: Tumor suppressor gene p53 is decreased in cancer cells which upregulates antioxidants genes such as MnSOD2, tumor protein P53-inducible nuclear protein 1 (TP53INP 1), GPX, TP53-induced glycolysis and apoptosis regulator (TIGAR), and SESN 1/2, the sestrins, which encode antioxidant modulators of PRDXs for which the ROS levels are produced more in cancer cells but endogenous antioxidants balance the ROS levels [8].