TNF and cancer: Quercetin has anti-inflammatory activity that pulls out the nitric oxide, catalase, and cytokines, specifically TNF-α, IL-β, and IL-6, which are inflammatory mediators, and in the promoter region of pro-inflammatory genes which is transcribed by NF-κB transcription factor where the TNF-α induced is collected and the quercetin inhibits the expression of the genes and interrupts the lipid peroxidation or poly-unsaturated fatty acid that increases cancer propagation by prohibiting the enzyme lipoxygenase [124].