Webb et al. have developed a COVID-19-specific hyperinflammation score (cHIS) that uses six parameters to assess the inflammatory situation in COVID-19 [141]: fever, macrophage activation (hyperferritinemia), hematological dysfunction (neutrophil-to-lymphocyte ratio), hepatic injury (lactate dehydrogenase or aspartate aminotransferase), coagulopathy (D-dimer), and cytokinemia (C-reactive protein, interleukin-6, or triglycerides). Here, IL6 is linked to COVID-19.