These findings are compatible with previous studies using a mouse model of Alzheimer’s disease showing that Nrf2 deficiency correlated with exacerbated microgliosis and astrogliosis, as determined by an elevation of gene expression of Iba-1 and GFAP levels [23], and an increase in the number of both Iba-1 positive cells and GFAP positive cells [24]. Here, AIF1 is linked to early-onset autosomal dominant Alzheimer disease.