NR1H4 and metabolic dysfunction-associated steatotic liver disease: Wang et al. [131] studied the improvement effect of inulin polysaccharide (inulin) on HFD-induced NAFLD mice and found that inulin could activate the FXR-FGF15 pathway and reduce the expression of ASBT, thereby increasing the de novo synthesis of hepatic bile acids (to reduce hepatic lipid deposition), inhibit intestinal absorption of bile acids and promote their efflux.