Polysaccharides can regulate the expression of FXR-related target genes, such as CYP7A1 (a key enzyme in the classical pathway of BAs synthesis), lipid metabolism-related SREBP1c and small intestinal brush border sodium-dependent bile acid transporter (ASBT, responsible for bile acid absorption), promote bile acid synthesis and excretion, and regulate lipids metabolism, thereby exerting an anti-NAFLD effect [93,132]. This evidence concerns the gene SLC10A2 and metabolic dysfunction-associated steatotic liver disease.