Hif1a is a master gene that regulates cellular and homeostatic states in response to hypoxia via regulation of genes such as Infβ, Tnfα and Il6 [100,101], each of which can severely alter homeostasis of MZB cells, a cell population now recognized as an early innate immune mediator of SS [20,22]. The gene discussed is HIF1A; the disease is synovial sarcoma.