Therefore, according to the literature data, the two identified upregulated miRNAs (hsa-miR-503-5p and hsa-miR-200b-3p) for the unfavorable prognosis group in TMPRSS2-ERG-positive, locally advanced PCa may be involved in an increase in cell motility and an inhibition of apoptosis, promoting cell proliferation, invasion, and migration. Here, TMPRSS2 is linked to posterior cortical atrophy.