Thus, based on the relative expression of mRNAs and miRNAs obtained by qPCR in the primary tumor, the most prospective markers were identified and a prognostic model (ALDH3A2 + ODF2 + QSOX2 + hsa-miR-503-5p + ISUP + pT) was constructed, designed to forecast the recurrence risk for TMPRSS2-ERG-positive, locally advanced PCa. This evidence concerns the gene ERG and posterior cortical atrophy.