Among grade 2 meningioma, Group 2P, i.e., grade 2 meningioma undergoing anaplastic transformation, had a significantly higher percentage of SOX2-positive cases than Groups 2B and 2R (100 vs 47.4% and 100 vs 64.3%; p = 0.0016 and p = 0.0391, respectively; Fisher exact test). The gene discussed is SOX2; the disease is meningioma.