The gene encoding SOX2 is located on the long arm of chromosome 3 and the increase of its expression has been correlated with growth, tumorigenesis, chemo-resistance and metastatic capacity in at least 25 different types of cancer, including ovary, lung, skin, brain, breast, prostate, pancreas and, importantly, brain tumors [9,22]. Here, SOX2 is linked to brain neoplasm.