Namely, SOX2 mRNA levels were remarkably lower in the IHC negative (0) meningioma as compared with SOX2 IHC positive ones (relative medians 0.0350 [0.0085; 0.0710] vs 0.2400 [0.1018; 0.4665], p < 0.001, Mann–Whitney U test) (Supplementary Figure S2C). Here, SOX2 is linked to meningioma.