Furthermore, downregulation of the oncogenes (EGFR, VEGFR, PDGFR, HER2) accompanied by upregulation of the tumor suppressor genes (p53, p73, p21, RB, BRCA1/BRCA2, PTEN gene) can also orchestrate effective apoptosis in a tumor cell. The gene discussed is BRCA2; the disease is neoplasm.