The systematic assessment of p53 immunohistochemical expression in TP53-mutant tumors has shown three possible aberrant patterns of p53: overexpression (strong expression in >70–80% of tumor cell, accounting for 85.6% of cases); complete loss (11.5% of cases); and cytoplasmic expression (1.9% of cases) [53]. Here, TP53 is linked to neoplasm.