The in vivo middle cerebral artery occlusion (MCAO) animal model and the in vitro OGD stroke model are used to study the mechanism of ischemic stroke induction by activating the NF-κB pathway, NLRP3 inflammasome, and triggering a vicious cycle of oxidative stress, leading to neurotoxicity [95,97]. This evidence concerns the gene NLRP3 and Stroke.