The in vivo middle cerebral artery occlusion (MCAO) animal model and the in vitro OGD stroke model are used to study the mechanism of ischemic stroke induction by activating the NF-κB pathway, NLRP3 inflammasome, and triggering a vicious cycle of oxidative stress, leading to neurotoxicity [95,97]. Here, NLRP3 is linked to ischemic stroke.