Although differences of albumin misfolding in the sera from the healthy 74-year-old volunteers, elderly subjects with mild cognitive impairment, and elderly patients with Alzheimer’s disease could not be directly determined, misfolded albumin in the cerebrospinal fluid of patients with Alzheimer’s appeared to have greater hydrophobic effects on bilayer membranes [15]. The gene discussed is ALB; the disease is early-onset autosomal dominant Alzheimer disease.