As shown in the figure, the level of Ptger4 in the liver macrophages of NASH mice was significantly increased; in addition, biomarkers of the mTOR complex (Mtor), ER stress (Atf4, Chop), and polarization (Nos2, Mrc1) were also significantly different and correlated (Figure S1D,E). This evidence concerns the gene NOS2 and metabolic dysfunction-associated steatohepatitis.