NPC1 and atherosclerosis: Xu et al. found that simvastatin upregulates NPC1 via CYP7A1/LXRα signaling in ox-LDL-loaded macrophages to promote FC efflux from the lysosome, reduce the secretion of proinflammatory cytokines, and inhibit the M1 polarization phenotype, which is important for atherosclerosis intervention [36].