As shown in the figure, the level of Ptger4 in the liver macrophages of NASH mice was significantly increased; in addition, biomarkers of the mTOR complex (Mtor), ER stress (Atf4, Chop), and polarization (Nos2, Mrc1) were also significantly different and correlated (Figure S1D,E). Here, ATF4 is linked to metabolic dysfunction-associated steatohepatitis.