CASP3 and cancer: Concerning their anticancer activity, recent studies have demonstrated the potential of forskolin in effective cancer therapeutics in U937 acute myeloid leukemia cell lines, specifically by enhancing the antiproliferative effects of a small molecule inhibitor, GSKJ4, by apoptotic cell death, as well as down-regulation of the BCL2 protein, caspase 3 activation and PARP protein cleavage.