SPP1 and melanoma: For the melanoma FTMs, as shown in Figure 4a, most of the EMT-inducing genes were significantly more expressed in the RF-FTMs compared to that in the PF-FTMs including TGFβ3 (* p < 0.05 in AN), SPARC (* p < 0.05 in both AN and M14), ITGα5 (* p < 0.05 in M14), SPP1 (* p < 0.05 in M14), TMEFF1 (* p < 0.05 in M14), ZEB2 (* p < 0.05 in M14) and FZD7 (*** p < 0.001 in M14).