In the field of cancer treatment, chemotherapeutic drugs can mediate pyroptosis through the caspase-3/GSDME pathway, thereby enhancing the effect of chemotherapy; for instance, a Cordyceps militaris extract can induce caspase-3-dependent pyroptosis in A549 cells through caspase-3/PARP and caspase-3/GSDME pathways [45]. Here, GSDME is linked to cancer.