To better understand the role of the TRAIL-R2 in Aβ-mediated neurotoxicity, we generated an AD phenotype in TRAIL-R−/− mice, by performing stereotaxic injection of the neurotoxic oligomer Aβ1-42 into the dentate gyrus of the hippocampus. The gene discussed is TNFRSF10B; the disease is Alzheimer disease.