MAPT and Alzheimer disease: Further, exosomal tau derived from AD brain were more transmissible than exosomal tau derived from non-demented controls, where injection into aged mouse brain led to abnormally phosphorylated tau accumulated in glutamic acid decarboxylase 67 (GAD67) GABAergic interneurons and inhibited postsynaptic currents, suggesting the cell type-specific susceptibility of tau pathology in the progression of tau pathology [45].