BRD2 and Alzheimer disease: In colon tissue specimens, significantly elevated methylation values were detected in CpG position 1 (CpG 1) of non-tumorous samples (N, AD-NAT, CRC-NAT, and IBD) compared to CpG position 2 (CpG 2), 3 (CpG 3), and mean methylation values (p ≤ 0.01) (Figure 1A, left).