GJA1 and oculodentodigital dysplasia: These hydrophobic residue positions are also frequently found to be hot spots for inherited disease-linked connexin mutants, such as oculodentodigital dysplasia-linked mutants in another α-connexin Cx43 (L7, L11) [44] and CMT1X-linked mutants in a β-connexin Cx32 on equivalent positions (W3, L9, L10) [37].