LCA has been shown to significantly alter the chemosensitivity of R482-HEK293 (ABCG2-transfected HEK293 human cells), S1-M1-80 (human colon cancer) and H460-MX20 (human non-small-cell lung cancer NSCLC) cells. The gene discussed is ABCG2; the disease is non-small cell lung carcinoma.