MRC1 and cancer: With regard to the PV identified, considering those reported in ClinVar and those not previously reported, a total of 96 (96/146) patients had a PV in one of the MMR genes; of these, 69.79% (67/96) had a first-degree cancer family history; 70.83% (69/96) were women, and 29.17% (29/96) were men.