As a first step, we confirmed the induction of chronic colitis by DSS-treatment in the colon of Ptch1+/− mice (Figure 8A) and, similarly to DSS-treated C57BL/6 WT mice, we found a significant increase of Gfap (+102.69%, p = 0.0052, Figure 8B,C), indicative of astrogliosis in the hippocampus of the Ptch1+/− mice but not in the cerebellum (Figure 8D,E). This evidence concerns the gene PTCH1 and Chronic colitis.