Therefore, it is possible that a reduced expression of or a defective mutation in OLA1 may lead to a lesion in the vascular endothelium, which occurs at the early stages of the development of atherosclerosis, or that overexpression of OLA1 promotes neovascularization by ECs of vasa vasorum, leading to plaque growth, plaque destabilization, and thromboembolic events in atherosclerotic lesions. This evidence concerns the gene OLA1 and atherosclerosis.