Autoantibodies against a wide range of blood proteins have been documented in COVID-19 patients and SARS-CoV-2 vaccinees, the targets of which include phospholipids and phospholipid-binding proteins [25]; lupus anticoagulant, cardiolipin (CL), and the cardiolipin-binding proteins phosphatidylserine/prothrombin (Factor 2), platelet glycoprotein Ib (GP1b) and beta-2 glycoprotein I (β2GPI) [7,25,26,27,28,29]; PF4 [30,31,32,33] von Willebrand factor (VWF), ADAMTS13 (von Willebrand factor-cleaving protease or VWFCP), and Factors, IX, X and Xa [34,35,36,37,38]. The gene discussed is VWF; the disease is COVID-19.