For CAC with UC, these co-existing variants were scattered from IL12Rß1, IL12Rß2, IL23R, OSMR, JAK2, TYK2, STAT1, STAT3 and STAT6, but for CAC with CRC, only two genes were involved (JAK2 and STAT4) (Table 3). This evidence concerns the gene TYK2 and colorectal carcinoma.