For CAC with UC, these co-existing variants were scattered from IL12Rß1, IL12Rß2, IL23R, OSMR, JAK2, TYK2, STAT1, STAT3 and STAT6, but for CAC with CRC, only two genes were involved (JAK2 and STAT4) (Table 3). Here, STAT4 is linked to colorectal carcinoma.