HPRT1 and cancer: The Jagged2 (JAG2), Aurora Kinase A (AURKA), Phosphoglycerate Kinase 1 (PGK1), and Hypoxanthine Guanine Phosphoribosyltransferase 1 (HPRT1) genes were previously shown to be up-regulated in EC compared to the control samples, with a stepwise elevation in protein expression corresponding to the cancer grade [7] In the present study, all four genes (JAG2, AURKA, PGK1, and HPRT1) were significantly up-regulated in EC tissues from obese women.