In cancer, CD68+ macrophages located around the tumor core contributed to the EMT process by triggering the downregulation of E-cadherin and the upregulation of vimentin, N-cadherin, and Snail in the epithelial and cancer cells via the release of TGF-β [112,115,116], a process potentially present in IPF as well. The gene discussed is TGFB1; the disease is cancer.