CD4 and autoimmune thyroid disease: For instance, Okajima et al., and Rydzewska et al. [28,42] highlighted the fact that autoimmune thyroid diseases, including Graves’ disease and Hashimoto’s thyroiditis, as well as hypothyroidism, which can be developed following Hashimoto’s thyroiditis disease, are characterized by intrathyroidal infiltration of the T lymphocytes CD4+ and CD8+, which are reactive to self-thyroid antigens.