In the project, we hypothesize that AQ exerts its anticancer efficacy in majority of breast cancer subtypes namely ER, PR positive breast cancer types; triple negative breast cancer (TNBC); and human epidermal growth factor receptor 2 positive (HER2+) breast cancer cell types due to its ability to induce apoptosis and to inhibit autophagy in various cancers. Here, ESR1 is linked to breast cancer.