Additionally, we observed downregulation of genes such as POLR1A, POLR1D, POLR1E, TAF1B, LAMP1, and CDKN1A (Figure 10B) in response to AQ treatment demonstrating the role of AQ in regulating RNA polymerase subunits and effect on overall gene transcription in breast cancer [58,59,60]. This evidence concerns the gene POLR1E and breast cancer.