POLR1D and breast cancer: Additionally, we observed downregulation of genes such as POLR1A, POLR1D, POLR1E, TAF1B, LAMP1, and CDKN1A (Figure 10B) in response to AQ treatment demonstrating the role of AQ in regulating RNA polymerase subunits and effect on overall gene transcription in breast cancer [58,59,60].