(+)MK-801 has been chosen because it induces, by noncompetitive blocking of NMDA receptors [30], cognitive disruptions similar to those associated with dementia [31] and schizophrenia [29,32], which were the potential therapeutic targets for these prototype dual-acting compounds combining the pharmacophores relevant for PDE10A and 5-HT1AR/5-HT7R activity [10]. The gene discussed is PDE10A; the disease is dementia.