Additionally, hypercholesterolemia can also contribute to platelet hyperreactivity via direct oxidized LDL (oxLDL)-platelet membrane interaction via scavenger receptors such as CD36 and signalling pathways including Src family kinases (SFK), mitogen-activated protein kinases (MAPK) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase [19,20,21,22]. This evidence concerns the gene WNK2 and familial hypercholesterolemia.