ADIPOQ and obesity due to melanocortin 4 receptor deficiency: We have also previously demonstrated that 6 h of adiponectin treatment in human primary myotubes derived from lean individuals increases AdipoR1 but not AdipoR2 mRNA expression, whereas myotubes derived from individuals who had obesity or obesity and diabetes did not alter AdipoR1 or AdipoR2 [21].