SOX2 and Alzheimer disease: miR-140-5p is also upregulated in post mortem brains from AD patients, compared to cognitively normal controls, causing a deleterious circle as it directly targets A Disintegrin and Metalloproteinase 10 (ADAM10) and SRY-box transcription factor 2 (SOX2), a transcription factor that positively regulates ADAM10 transcription.