Decreased % CD8+ EM and CM T cells in active SLE vs. HC (p < 0.01 and p < 0.05, respectively). Increased % naïve CD8+ T cells in active SLE vs. HC (p < 0.001) and vs. inactive SLE (p < 0.05). Positive correlation between % naïve CD8+ T cells and SLEDAI score (r2 = 0.14, p = 0.01). Negative correlation between % TEMRA CCR7−CD45RA+ CD8+ T cells and SLEDAI score (r2 = 0.09, p = 0.05). Here, CD8A is linked to systemic lupus erythematosus.