Elevated CD8+ T cell numbers in SLE with active renal disease vs. HC (p < 0.005) [62] and SLE without active renal disease (p < 0.001) [62], (p < 0.005) [135], (p < 0.0001) [138]. Nearly 70% of urinary CD8+T cells express the EM phenotype [62]. This evidence concerns the gene CD8A and systemic lupus erythematosus.