In contrast, others have shown decreased cytotoxic capacity in CD8+ T cells in SLE, as evidenced by reduced cytotoxic molecule expression and degranulation capacity [72,102] as well as diminished effector function in response to viral antigens [29,103], decreased IFN-γ intracellular expression in response to PMA stimulation [104,105], and decreased non-restricted cytolytic activity in vitro [106,107,108]. This evidence concerns the gene CD8A and systemic lupus erythematosus.