The majority of studies focusing on this subpopulation have reported elevated frequencies of CD3+CD8+CD28− T cells in peripheral blood in SLE [68,69] with some reporting a correlation between CD28− T cell frequencies and systemic lupus erythematosus disease activity index (SLEDAI) and an association with presence of LN [68]. The gene discussed is CD8A; the disease is systemic lupus erythematosus.