CD8A and lobular neoplasia: Increased CD8+T cell counts/mL in urine associated with active renal disease and correlated with SLEDAI (r = 0.68, p < 0.001) [62], (r = 0.7641, p < 0.0001) [138].Urine CD8+ T cell counts used to discriminate patients with active LN and inactive LN and active LN vs. no renal involvement [135,138]. No correlation between urinary T-cell counts and renal activity index [135].